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All of the B vitamins are needed for a healthy, functioning nervous system and several are needed to synthesize serotonin (16).

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It comes from Griffonia simplicifolia, an African woody shrub. But we’ve put it in the amino acid category since it’s so closely associated with tryptophan. S., Canada, and the United Kingdom, 5-HTP is sold as an over-the-counter supplement for ADHD, anxiety, depression, fibromyalgia, migraines, sleep disorders, and weight loss (7).We prefer tryptophan supplements not just because studies have not conclusively found that 5-HTP helps depression, but because 5-HTP is intended for long-term use.While it’s increasing serotonin, it’s depleting other neurotransmitters like dopamine.But since protein blocks serotonin synthesis, eating a meal containing protein will actually cause both tryptophan and serotonin levels drop.However, tryptophan supplements can increase brain serotonin even though eating foods containing tryptophan does not (5).Several other brain-related disorders besides depression are related to low serotonin, including autism, ADHD, bipolar disorder, sleep disorders, and schizophrenia (3).

Many people with depression or other serotonin deficiency symptoms and conditions are searching for better ways to increase serotonin levels naturally without the use of drugs.

There are several co-factors required to make the most commonly used serotonin supplements do their job.

Conversely, there are times when these supplements can react adversely with medications or other serotonin supplements, and you need to know about those, too.

Tryptophan supplements fell out of favor when a contaminated batch from Japan caused thousands to fall ill in the 1980s.

For decades, manufacturers shied away from selling this supplement, but it’s now readily available and widely known to be safe.

It’s believed that low serotonin is the underlying cause of depression.