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To elucidating

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They are currently declining around the world, largely due to the effects of climate change and local anthropogenic issues.Temperature stress in particular has been associated with significant coral mortality over the last 30 years due to adverse effects on the relationship between reef-building corals and their algal endosymbionts from the genus Symbiodinium.

Shortly after he began these investigation changes, Horecker was approached by future Nobel laureate Arthur Kornberg, who was convinced that enzymes were the key to understanding intracellular biochemical processes.Horecker and Kornberg continued to collaborate, this time on the isolation of DPN and TPN.By 1948 they had amassed a huge supply of the coenzymes and were able to present Otto Warburg, the discoverer of TPN, with a gift of 25 mg of the enzyme when he came to visit.Horecker also served as president of the American Society of Biological Chemists (now the American Society for Biochemistry and Molecular Biology) in 1968.This site uses cookies to improve performance by remembering that you are logged in when you go from page to page.In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie.

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This marked the beginning of Horecker's lifelong involvement with the pentose phosphate pathway.

During World War II, Horecker left Chicago and got a job at the National Institutes of Health (NIH) in Frederick S.

Joined by Horecker's first postdoctoral student, J. Seegmiller, they worked out a new method for the preparation of glucose 6-phosphate and 6-phosphogluconate, both of which were not yet commercially available.

As reported in the (JBC) Classic reprinted here, they purified 6-phosphogluconate dehydrogenase from brewer's yeast (1), and by coupling the reduction of TPN to its reoxidation by pyruvate in the presence of lactic dehydrogenase, they were able to show that the first product of 6-phosphogluconate oxidation, in addition to carbon dioxide, was ribulose 5-phosphte.

Horecker also collaborated with Heppel on the isolation of cytochrome reductase from yeast and eventually accomplished the first isolation of the flavoprotein from mammalian liver.